Node.js is an open source Javascript runtime environment for easily building server-side and networking applications. The platform runs on Linux, OS X, FreeBSD, and Windows, and its applications are written in JavaScript. Node.js applications can be run at the command line but we will teach you how to run them as a service, so they will automatically restart on reboot or failure, so you can use them in a production environment.
In this tutorial, we will cover setting up a production-ready Node.js environment that is composed of two Ubuntu 14.04 servers; one server will run Node.js applications managed by PM2, while the other will provide users with access to the application through an Nginx reverse proxy to the application server.
Source: How To Set Up a Node.js Application for Production on Ubuntu 14.04 | DigitalOcean
Good tutorial. You can also do the reverse proxy with Apache.